diff --git a/BUCK.oss b/BUCK.oss
index 13d5518801a2..fb2e03ac8ddc 100644
--- a/BUCK.oss
+++ b/BUCK.oss
@@ -52,7 +52,7 @@ cxx_library(
             "**/*.pb.h",
         ],
     ),
-    compiler_flags = ['-Os', '-fexceptions', '-frtti', '-Wno-shadow', '-Wno-unknown-pragmas', '-Wno-unused-variable', '-Wno-sign-compare', '-Icaffe2', '-Imodules', '-DEIGEN_NO_DEBUG', '-DCAFFE2_USE_LITE_PROTO', '-DCAFFE2_USE_GOOGLE_GLOG', '-DCAFFE2_RNN_NO_TEXT_FORMAT', '-DGEMMLOWP_ALLOW_SLOW_SCALAR_FALLBACK=1', '-DCAFFE2_IS_XPLAT_BUILD', '-DSTRIP_ERROR_MESSAGES', '-DUSE_INTERNAL_PTHREADPOOL_IMPL', '-DCAFFE2_USE_HPTT'],
+    compiler_flags = ['-Os', '-fexceptions', '-frtti', '-Wno-shadow', '-Wno-unknown-pragmas', '-Wno-unused-variable', '-Wno-sign-compare', '-Icaffe2', '-Imodules', '-DEIGEN_NO_DEBUG', '-DCAFFE2_USE_GOOGLE_GLOG','-DGEMMLOWP_ALLOW_SLOW_SCALAR_FALLBACK=1', '-DCAFFE2_IS_XPLAT_BUILD', '-DSTRIP_ERROR_MESSAGES', '-DUSE_INTERNAL_PTHREADPOOL_IMPL'],
     preferred_linkage = "static",
     platform_preprocessor_flags = [['windows', ['-D_WINDOWS', '-D_WIN32', '-DWIN32', '-DNOMINMAX', '-D_CRT_SECURE_NO_WARNINGS', '-D_USE_MATH_DEFINES']], ['windows.*64$', ['-D_WIN64']]],
     preprocessor_flags = ['-DUSE_INTERNAL_PTHREADPOOL_IMPL'],
diff --git a/buckbuild.bzl b/buckbuild.bzl
index 4954e10d561e..0d0f56007aef 100644
--- a/buckbuild.bzl
+++ b/buckbuild.bzl
@@ -246,7 +246,6 @@ def get_aten_preprocessor_flags():
     ATEN_PREPROCESSOR_FLAGS = _COMMON_PREPROCESSOR_FLAGS + [
         "-DCPU_CAPABILITY_DEFAULT",
         "-DCPU_CAPABILITY=DEFAULT",
-        "-DCAFFE2_USE_LITE_PROTO",
         "-DATEN_CUDNN_ENABLED_FBXPLAT=0",
         "-DATEN_MKLDNN_ENABLED_FBXPLAT=0",
         "-DATEN_MKLDNN_ACL_ENABLED_FBXPLAT=0",
diff --git a/build.bzl b/build.bzl
index 8fd15f4e9c42..50cd79234936 100644
--- a/build.bzl
+++ b/build.bzl
@@ -16,11 +16,9 @@ def define_targets(rules):
         src = "caffe2/core/macros.h.in",
         out = "caffe2/core/macros.h",
         definitions = [
-            "CAFFE2_BUILD_SHARED_LIBS",
             "CAFFE2_PERF_WITH_AVX",
             "CAFFE2_PERF_WITH_AVX2",
             "CAFFE2_PERF_WITH_AVX512",
-            "CAFFE2_USE_EXCEPTION_PTR",
             "CAFFE2_USE_CUDNN",
             "USE_MKLDNN",
             "CAFFE2_USE_ITT",
diff --git a/caffe2/core/macros.h.in b/caffe2/core/macros.h.in
index 2497effd8637..bb38257d5bbd 100644
--- a/caffe2/core/macros.h.in
+++ b/caffe2/core/macros.h.in
@@ -5,25 +5,16 @@
 
 #pragma once
 
-#cmakedefine CAFFE2_BUILD_SHARED_LIBS
-#cmakedefine CAFFE2_FORCE_FALLBACK_CUDA_MPI
 #cmakedefine CAFFE2_HAS_MKL_DNN
-#cmakedefine CAFFE2_HAS_MKL_SGEMM_PACK
 #cmakedefine CAFFE2_PERF_WITH_AVX
 #cmakedefine CAFFE2_PERF_WITH_AVX2
 #cmakedefine CAFFE2_PERF_WITH_AVX512
-#cmakedefine CAFFE2_THREADPOOL_MAIN_IMBALANCE
-#cmakedefine CAFFE2_THREADPOOL_STATS
-#cmakedefine CAFFE2_USE_EXCEPTION_PTR
-#cmakedefine CAFFE2_USE_ACCELERATE
 #cmakedefine CAFFE2_USE_CUDNN
-#cmakedefine CAFFE2_USE_EIGEN_FOR_BLAS
 #cmakedefine CAFFE2_USE_FBCODE
 #cmakedefine CAFFE2_USE_GOOGLE_GLOG
 #cmakedefine CAFFE2_USE_LITE_PROTO
 #cmakedefine CAFFE2_USE_MKL
 #cmakedefine USE_MKLDNN
-#cmakedefine CAFFE2_USE_NVTX
 #cmakedefine CAFFE2_USE_ITT
 
 #ifndef EIGEN_MPL2_ONLY
@@ -52,19 +43,13 @@
   {"USE_GLOO", "${USE_GLOO}"}, \
   {"USE_NNPACK", "${USE_NNPACK}"}, \
   {"USE_OPENMP", "${USE_OPENMP}"}, \
-  {"FORCE_FALLBACK_CUDA_MPI", "${CAFFE2_FORCE_FALLBACK_CUDA_MPI}"}, \
   {"HAS_MKL_DNN", "${CAFFE2_HAS_MKL_DNN}"}, \
-  {"HAS_MKL_SGEMM_PACK", "${CAFFE2_HAS_MKL_SGEMM_PACK}"}, \
   {"PERF_WITH_AVX", "${CAFFE2_PERF_WITH_AVX}"}, \
   {"PERF_WITH_AVX2", "${CAFFE2_PERF_WITH_AVX2}"}, \
   {"PERF_WITH_AVX512", "${CAFFE2_PERF_WITH_AVX512}"}, \
-  {"USE_EXCEPTION_PTR", "${CAFFE2_USE_EXCEPTION_PTR}"}, \
-  {"USE_ACCELERATE", "${CAFFE2_USE_ACCELERATE}"}, \
-  {"USE_EIGEN_FOR_BLAS", "${CAFFE2_USE_EIGEN_FOR_BLAS}"}, \
   {"USE_LITE_PROTO", "${CAFFE2_USE_LITE_PROTO}"}, \
   {"USE_MKL", "${CAFFE2_USE_MKL}"}, \
   {"USE_MKLDNN", "${USE_MKLDNN}"}, \
-  {"USE_NVTX", "${CAFFE2_USE_NVTX}"}, \
   {"USE_ITT", "${CAFFE2_USE_ITT}"}, \
   {"USE_ROCM_KERNEL_ASSERT", "${USE_ROCM_KERNEL_ASSERT}"}, \
   {"USE_CUSPARSELT", "${USE_CUSPARSELT}"}, \
diff --git a/cmake/Dependencies.cmake b/cmake/Dependencies.cmake
index 091317acb275..49661044406f 100644
--- a/cmake/Dependencies.cmake
+++ b/cmake/Dependencies.cmake
@@ -161,7 +161,6 @@ message(STATUS "Trying to find preferred BLAS backend of choice: " ${BLAS})
 
 if(BLAS STREQUAL "Eigen")
   # Eigen is header-only and we do not have any dependent libraries
-  set(CAFFE2_USE_EIGEN_FOR_BLAS ON)
 elseif(BLAS STREQUAL "ATLAS")
   find_package(Atlas REQUIRED)
   include_directories(SYSTEM ${ATLAS_INCLUDE_DIRS})
@@ -201,7 +200,6 @@ elseif(BLAS STREQUAL "MKL")
     set(BLAS_LIBRARIES ${MKL_LIBRARIES})
   else()
     message(WARNING "MKL could not be found. Defaulting to Eigen")
-    set(CAFFE2_USE_EIGEN_FOR_BLAS ON)
     set(CAFFE2_USE_MKL OFF)
   endif()
 elseif(BLAS STREQUAL "NVPL")
@@ -939,7 +937,6 @@ if(USE_MPI)
         message(STATUS "Found OpenMPI with CUDA support built.")
       else()
         message(WARNING "OpenMPI found, but it is not built with CUDA support.")
-        set(CAFFE2_FORCE_FALLBACK_CUDA_MPI 1)
       endif()
     endif()
   else()
diff --git a/cmake/MiscCheck.cmake b/cmake/MiscCheck.cmake
index 433d96ebfd23..53da086b14b6 100644
--- a/cmake/MiscCheck.cmake
+++ b/cmake/MiscCheck.cmake
@@ -2,8 +2,6 @@ include(CheckCXXSourceCompiles)
 include(CheckCXXCompilerFlag)
 include(CMakePushCheckState)
 
-set(CAFFE2_USE_EXCEPTION_PTR 1)
-
 # ---[ Check if we want to turn off deprecated warning due to glog.
 if(USE_GLOG)
   cmake_push_check_state(RESET)
@@ -109,9 +107,6 @@ if(IOS AND (${IOS_ARCH} MATCHES "armv7*"))
   add_definitions("-Wno-deprecated-declarations")
 endif()
 
-# ---[ Create CAFFE2_BUILD_SHARED_LIBS for macros.h.in usage.
-set(CAFFE2_BUILD_SHARED_LIBS ${BUILD_SHARED_LIBS})
-
 if(USE_NATIVE_ARCH)
   check_cxx_compiler_flag("-march=native" COMPILER_SUPPORTS_MARCH_NATIVE)
   if(COMPILER_SUPPORTS_MARCH_NATIVE)