LOCUS       HSTMPO1      2509 bp    DNA             PRI       01-JUL-1995
DEFINITION  Human thymopoietin (TMPO) gene, exon 1.
ACCESSION   U18266
VERSION     U18266.1  GI:885676
KEYWORDS    .
SEGMENT     1 of 6
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Harris,C.A., Andryuk,P.J., Cline,S.W., Siekierka,J.J. and
            Goldstein,G.
  TITLE     Structure and mapping of the human thymopoietin (TMPO) gene and
            relationship of TMPO beta to rat lamin-associated polypeptide 2
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Harris,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-1994) Crafford A. Harris, Immunobiology Research
            Institute, Route 22 East, Annandale, NJ 08801-0999, USA
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22; 64% (% distance from centromere to telomere)"
                     /clone="P1.516 (DMPC-HFFno.1B-0943F)"
                     /clone_lib="DuPont Merck Hum Fibroblast P1 Library no.1
                     Series B (compressed) (Genome Systems Inc)"
     5'UTR           one-of(1888,1901)..2200
                     /gene="TMPO"
     gene            join(1888..2509,U18267.1:1..270,U18268.1:1..309,
                     U18270.1:1..6905,U18269.1:1..128,U18271.1:1..3234)
                     /gene="TMPO"
     exon            one-of(1888,1901)..2479
                     /gene="TMPO"
                     /number=1
     CDS             join(2201..2479,U18267.1:120..246,U18268.1:130..288,
                     U18270.1:4691..4788,U18269.1:82..>128)
                     /gene="TMPO"
                     /codon_start=1
                     /product="thymopoietin beta"
                     /protein_id="AAB60434.1"
                     /db_xref="GI:885684"
                     /translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
                     LTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKP
                     RQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSST
                     PLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVE
                     HNQSYSQAGITETEWTSGS"
     CDS             join(2201..2479,U18267.1:120..246,U18268.1:130..288,
                     U18270.1:39..1558)
                     /gene="TMPO"
                     /codon_start=1
                     /product="thymopoietin alpha"
                     /protein_id="AAB60433.1"
                     /db_xref="GI:885683"
                     /translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
                     LTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKP
                     RQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSST
                     PLPTISSSAENTRQNGSNDSDRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGF
                     FQGISFPEISTRPPLGSTELQAAKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNL
                     FISCKSSHDRCLEKSSSSSSQPEHSAMLVSTAASPSLIKETTTGYYKDIVENICGREK
                     SGIQPLCPERSHISDQSPLSSKRKALEESESSQLISPPLAQAIRDYVNSLLVQGGVGS
                     LPGTSNSMPPLDVENIQKRIDQSKFQETEFLSPPRKVPRLSEKSVEERDSGSFVAFQN
                     IPGSELMSSFAKTVVSHSLTTLGLEVAKQSQHDKIDASELSFPFHESILKVIEEEWQQ
                     VDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLD
                     LALCRAYEAAASALQIATHTAFVAKAMQADISEAAQILSSDPSRTHQALGILSKTYDA
                     ASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGE
                     VCKVIKKRGNKH"
BASE COUNT      667 a    587 c    656 g    599 t
ORIGIN      
        1 gaattcagat agaatgtaga caagagggat ggtgaggaaa acctacggca agcagctcta
       61 taatttctgg aaagtgacca ggaggctcgt ggatgatggc aggaaggaga gtagaaagtg
      121 atttagccag aagatatgaa cttcaaatat ttttgaagca gaaaagagca gaaatggttt
      181 ggaagtagca atcaggacca aagagaccac ccaaactcaa tagcccaacc tcttagcctt
      241 agggtatgca gaatctgaaa agtgtaatct caattttgga gctctacagc agtaaatctg
      301 caagtaacca cctgtagcta atgtccaggg attaaaaaaa agataatgaa aatgtttttg
      361 cccaggaaac attaatttca ggcgtatcta gaatgcagtt cttgcattat acgtactggg
      421 ttaccagtca ttgcaaagtc atggtccttt gcctctcagc tcagttcccc ttctgaagat
      481 aaaaacattt gcctatgtgt ccagggaagc tgtgaggaca aaaaaccaag caacttttac
      541 aagggatcat aaaaacctac ctaacaactt gctaattaaa acctgatttt taatttgcat
      601 tattgagctt aataccattg cttaaatgta tgtgaatact gagattttta taaaggaatt
      661 agttacctct aggaaaataa ttatcactaa aagaaataat atcgcaattt gaataaaagt
      721 aagtcgctta aatcatagga aacattttta gtgaaggcgt ttgttttaaa tgtattctaa
      781 cctagcaatg tagaaagcag gcaaacattt aaaaaaaatt taaccagttt ctaaaacata
      841 gtttggagct cagattctgg ggaaatgatt aacacaccct acatccaagg tctcctttcc
      901 tttctagaaa gaaagcatct ttaaacatac atattcatca gaaatacaaa tatttgtcat
      961 cagtgatact aatttccagg caaacatttt aattgcagtc aatgtattag attctaccag
     1021 gttttaattt ggatcggtaa tacgggtttg attagggttc taggcctaat tataggtcac
     1081 tagtcttcct ttaggattat gtaccatctg ttattttaaa ttgaccattg agggggttcc
     1141 caagggttct ccttcgtttt gttatcaaac gttaggttta ggattcttgc gggtggtggg
     1201 atccaaagcc agagacggtt tcaacaaaaa tgcaagcgcg aatttgtctt gcgtctgaac
     1261 gcactgttca aattaaacaa tttagacatg ccccaactat gacactaaga agtgaatggt
     1321 atagtacact tttgtcacaa attcaagggt aatttaagtg cccgatggta gaggtctggc
     1381 ttcccctggg tttctggaac aaaagaagcg ttcgcgagga gaggggtaac tccccgccct
     1441 ccccctccca aagtaaatca aatcaaggaa tatgagtgcc tgcagacaag cctcgcttct
     1501 tttcttcccc ttcagggcta gcgtttgggg aaggcaaggc tgcggctact cttggagctt
     1561 cagtgtcccg ggaggaagaa aggcccagcc aagggtcctc acactggcgt ggaattcggc
     1621 gcgttcgtag gcgatcgacc ccagagacga aagctgcttc tcaagctggg ggagggagag
     1681 gaaacggcgc acaaaagcag tacgacctgt cccttatcgg cgtctaaggg gaagggtgga
     1741 gaaaacgaaa acagaagcgg gccgggagcc tcggctcccg ccccagcgcc ttttaaactg
     1801 cgtttctacc tcctctcgct cagcgcggcg gctaatggaa cccgcgcgag ccgtctcgcc
     1861 aatcaccgcc gcgcttcctc ccgtcgcccg ccaatggcgg cgcgcgttct tggggcgtgg
     1921 gcgaagcagg ctgctcgcct cctgcctgta gtgtgtgggc tggggttggt gcgagcttcc
     1981 agcttggccg cagttggttc gtagttcggc tctggggtct tttgtgtccg ggtctggctt
     2041 ggctttgtgt ccgcgagttt ttgttccgct ccgcagcgct cttcccgggc aggagccgtg
     2101 aggctcggag gcggcagcgc ggtccccggc caggagcaag cgcgccggcg tgagcggcgg
     2161 cggcaaaggc tgtggggagg gggcttcgca gatccccgag atgccggagt tcctggaaga
     2221 cccctcggtc ctgacaaaag acaagttgaa gagtgagttg gtcgccaaca atgtgacgct
     2281 gccggccggg gagcagcgca aagacgtgta cgtccagctc tacctgcagc acctcacggc
     2341 tcgcaaccgg ccgccgctcc ccgccggcac caacagcaag gggcccccgg acttctccag
     2401 tgacgaagag cgcgagccca ccccggtcct cggctctggg gccgccgccg cgggccggag
     2461 ccgagcagcc gtcggcaggg taaggacgcg gggccggggc tacaaaggc
//
