ENTRY       EC 6.2.1.25                 Enzyme
NAME        benzoate---CoA ligase;
            benzoate---coenzyme A ligase;
            benzoyl-coenzyme A synthetase;
            benzoyl CoA synthetase (AMP forming)
CLASS       Ligases;
            Forming carbon-sulfur bonds;
            Acid-thiol ligases
SYSNAME     benzoate:CoA ligase (AMP-forming)
REACTION    ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
ALL_REAC    R01422
SUBSTRATE   ATP [CPD:C00002];
            benzoate [CPD:C00180];
            CoA [CPD:C00010]
PRODUCT     AMP [CPD:C00020];
            diphosphate [CPD:C00013];
            benzoyl-CoA [CPD:C00512]
COMMENT     Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
HISTORY     EC 6.2.1.25 created 1989
REFERENCE   1
  AUTHORS   Hutber, G.N. and Ribbons, D.W.
  TITLE     Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  JOURNAL   J. Gen. Microbiol. 129 (1983) 2413-2420.
REFERENCE   2  [PMID:2857161]
  AUTHORS   Schennen U, Braun K, Knackmuss HJ.
  TITLE     Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  JOURNAL   J. Bacteriol. 161 (1985) 321-5.
PATHWAY     ec00362  Benzoate degradation
            ec00627  Aminobenzoate degradation
            ec01100  Metabolic pathways
            ec01120  Microbial metabolism in diverse environments
ORTHOLOGY   K04105  4-hydroxybenzoate-CoA ligase
            K04110  benzoate-CoA ligase
GENES       RPJ: N234_07060
            REU: Reut_A1327
            REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
            CNC: CNE_1c14400(bclA)
            RME: Rmet_1224(bzdA)
            CTI: RALTA_A1325 RALTA_B1617
            CBW: RR42_m1521
            BGL: bglu_2g11460
            BUG: BC1001_2395
            BGE: BC1002_1980
            BGF: BC1003_1063
            BXE: Bxe_A1419 Bxe_C0896
            BPH: Bphy_1543
            BRH: RBRH_00494
            BPY: Bphyt_2700
            BPT: Bpet3574
            AXY: AXYL_05035
            RFR: Rfer_0216
            POL: Bpro_1624 Bpro_2983
            PNA: Pnap_2948
            VEI: Veis_0730
            DAC: Daci_0076
            DEL: DelCs14_0077
            VAP: Vapar_0089
            VPE: Varpa_0102
            CTT: CtCNB1_0097
            RTA: Rta_22340
            LCH: Lcho_3655
            EBA: ebA2757(bclA) ebA5301(bclA)
            AZO: azo3052(bzdA)
            AZA: AZKH_4514(bclA)
            AZI: AzCIB_4632
            TMZ: Tmz1t_3136
            SHD: SUTH_01659
            GME: Gmet_2143(bamY)
            GLO: Glov_2397
            GEO: Geob_0200(bamY)
            GEM: GM21_2825
            DMA: DMR_19390
            DPR: Despr_3172
            SAT: SYN_02896 SYN_02898
            BJA: blr1077
            BJU: BJ6T_11070
            BJP: RN69_05405
            BRA: BRADO6791
            BBT: BBta_0747 BBta_6637(badA)
            BRS: S23_67390
            AOL: S58_06690
            BRC: BCCGELA001_34230
            RPA: RPA0661(badA) RPA0669(hbaA)
            RPB: RPB_4656
            RPC: RPC_1016 RPC_1025
            RPD: RPD_0878 RPD_1526 RPD_1534
            RPE: RPE_0592 RPE_0604
            RPT: Rpal_0728 Rpal_0736
            RPX: Rpdx1_4117
            RVA: Rvan_0044
            RHZ: RHPLAN_60910
            SIL: SPO3697(badA-1)
            JAN: Jann_0669
            SWI: Swit_0829
            MAG: amb2869
            MAGX: XM1_2792(bclA)
            GYC: GYMC61_2828
            SCB: SCAB_8391
            AMD: AMED_8609(badA)
            PDX: Psed_1491
DBLINKS     ExplorEnz - The Enzyme Database: 6.2.1.25
            IUBMB Enzyme Nomenclature: 6.2.1.25
            ExPASy - ENZYME nomenclature database: 6.2.1.25
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
            BRENDA, the Enzyme Database: 6.2.1.25
            CAS: 95329-17-2
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