LOCUS       NP_001832                360 aa            linear   PRI 18-DEC-2001
DEFINITION  cannabinoid receptor 2 (macrophage) [Homo sapiens].
ACCESSION   NP_001832
PID         g4502929
VERSION     NP_001832.1  GI:4502929
DBSOURCE    REFSEQ: accession NM_001841.1
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Munro,S., Thomas,K.L. and Abu-Shaar,M.
  TITLE     Molecular characterization of a peripheral receptor for
            cannabinoids
  JOURNAL   Nature 365 (6441), 61-65 (1993)
  MEDLINE   93368659
   PUBMED   7689702
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Galiegue,S., Mary,S., Marchand,J., Dussossoy,D., Carriere,D.,
            Carayon,P., Bouaboula,M., Shire,D., Le Fur,G. and Casellas,P.
  TITLE     Expression of central and peripheral cannabinoid receptors in human
            immune tissues and leukocyte subpopulations
  JOURNAL   Eur. J. Biochem. 232 (1), 54-61 (1995)
  MEDLINE   96048028
   PUBMED   7556170
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Shire,D., Calandra,B., Rinaldi-Carmona,M., Oustric,D., Pessegue,B.,
            Bonnin-Cabanne,O., Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Molecular cloning, expression and function of the murine CB2
            peripheral cannabinoid receptor
  JOURNAL   Biochim. Biophys. Acta 1307 (2), 132-136 (1996)
  MEDLINE   96283804
   PUBMED   8679694
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X74328.1.
            Summary: The cannabinoid delta-9-tetrahydrocannabinol is the
            principal psychoactive ingredient of marijuana. The proteins
            encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1)
            gene have the characteristics of a guanine nucleotide-binding
            protein (G-protein)-coupled receptor for cannabinoids. They inhibit
            adenylate cyclase activity in a dose-dependent, stereoselective,
            and pertussis toxin-sensitive manner. These proteins have been
            found to be involved in the cannabinoid-induced CNS effects
            (including alterations in mood and cognition) experienced by users
            of marijuana. The cannabinoid receptors are members of family 1 of
            the G-protein-coupled receptors.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     Protein         1..360
                     /product="cannabinoid receptor 2 (macrophage)"
     Region          50..299
                     /region_name="7 transmembrane receptor (rhodopsin family)"
                     /db_xref="CDD:pfam00001"
                     /note="7tm_1"
     CDS             1..360
                     /pseudo
                     /gene="CNR2"
                     /db_xref="LocusID:1269"
                     /db_xref="MIM:605051"
                     /coded_by="NM_001841.1:127..1209"
ORIGIN      
        1 meecwvteia ngskdgldsn pmkdymilsg pqktavavlc tllgllsale nvavlylils
       61 shqlrrkpsy lfigslagad flasvvfacs fvnfhvfhgv dskavfllki gsvtmtftas
      121 vgsllltaid rylclrypps ykalltrgra lvtlgimwvl salvsylplm gwtccprpcs
      181 elfplipndy llswllfiaf lfsgiiytyg hvlwkahqhv aslsghqdrq vpgmarmrld
      241 vrlaktlglv lavllicwfp vlalmahsla ttlsdqvkka fafcsmlcli nsmvnpviya
      301 lrsgeirssa hhclahwkkc vrglgseake eaprssvtet eadgkitpwp dsrdldlsdc
      361 
//
