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<author>Driscoll P.C.</author>
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<author>Engh R.A.</author>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/MRNA" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>IPI</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ipi/IPI00479511">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>IPI</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ipi/IPI00910450">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>IPI</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ipi/IPI00953228">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>IPI</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pir/UKHUT">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PIR</database>
<rdfs:comment>A94004</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pir/I38098">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PIR</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/refseq/NP_000921.1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>RefSeq</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/refseq/NP_127509.1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>RefSeq</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/unigene/Hs.491582">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>UniGene</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1A5H">
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<database>PDB</database>
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<resolution rdf:datatype="http://www.w3.org/2001/XMLSchema#float">2.90</resolution>
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<rdf:Description rdf:about="#_5030303735300031">
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<chain>A/B=311-562</chain>
<chain>C/D=298-304</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1BDA">
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<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/X-Ray_Crystallography" />
<resolution rdf:datatype="http://www.w3.org/2001/XMLSchema#float">3.35</resolution>
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<chain>A/B=298-562</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1PK2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/NMR_Spectroscopy" />
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<rdf:Description rdf:about="#_5030303735300033">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Mapping_Statement" />
<chain>A=209-298</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1PML">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/X-Ray_Crystallography" />
<resolution rdf:datatype="http://www.w3.org/2001/XMLSchema#float">2.38</resolution>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300034">
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<chain>A/B/C=213-298</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1RTF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/X-Ray_Crystallography" />
<resolution rdf:datatype="http://www.w3.org/2001/XMLSchema#float">2.30</resolution>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300035">
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<chain>B=311-562</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1TPG">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/NMR_Spectroscopy" />
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<rdf:Description rdf:about="#_5030303735300036">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Mapping_Statement" />
<chain>A=36-126</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1TPK">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/X-Ray_Crystallography" />
<resolution rdf:datatype="http://www.w3.org/2001/XMLSchema#float">2.40</resolution>
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<chain>A/B/C=211-298</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1TPM">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/NMR_Spectroscopy" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300038">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Mapping_Statement" />
<chain>A=36-85</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdb/1TPN">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Resource" />
<database>PDB</database>
<method rdf:resource="http://purl.uniprot.org/core/NMR_Spectroscopy" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300039">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structure_Mapping_Statement" />
<chain>A=36-85</chain>
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<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1A5H">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1BDA">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1PK2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1PML">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1RTF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1TPG">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1TPK">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1TPM">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pdbsum/1TPN">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PDBsum</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/proteinmodelportal/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>ProteinModelPortal</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smr/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMR</database>
<rdfs:comment>126-210, 174-299, 212-334</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/string/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>STRING</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/merops/S01.232">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>MEROPS</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/glycosuitedb/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>GlycoSuiteDB</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pride/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PRIDE</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ensembl/ENST00000220809">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Transcript_Resource" />
<database>Ensembl</database>
<translatedTo rdf:resource="http://purl.uniprot.org/ensembl/ENSP00000220809" />
<transcribedFrom rdf:resource="http://purl.uniprot.org/ensembl/ENSG00000104368" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/geneid/5327">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>GeneID</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/kegg/hsa:5327">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>KEGG</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ucsc/uc003xos.2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>UCSC</database>
<rdfs:comment>human</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ucsc/uc003xot.2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>UCSC</database>
<rdfs:comment>human</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ucsc/uc010lxf.1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>UCSC</database>
<rdfs:comment>human</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/ctd/5327">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>CTD</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/genecards/GC08M042050">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>GeneCards</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/h-invdb/HIX0007476">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>H-InvDB</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/hgnc/9051">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>HGNC</database>
<rdfs:comment>PLAT</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/hpa/CAB009335">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>HPA</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/hpa/HPA003412">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>HPA</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/mim/173370">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>MIM</database>
<rdfs:comment>gene</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pharmgkb/PA33381">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PharmGKB</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/eggnog/prNOG16610">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>eggNOG</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/hovergen/HBG008633">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>HOVERGEN</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/inparanoid/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InParanoid</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/oma/TCGLRQY">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>OMA</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/orthodb/EOG9TQPVK">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>OrthoDB</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/phylomedb/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PhylomeDB</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/brenda/3.4.21.68">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>BRENDA</database>
<rdfs:comment>247</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pathway-interaction-db/amb2_neutrophils_pathway">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pathway_Interaction_DB</database>
<rdfs:comment>amb2 Integrin signaling</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/reactome/REACT_16888">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Reactome</database>
<rdfs:comment>Signaling by PDGF</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/reactome/REACT_604">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Reactome</database>
<rdfs:comment>Hemostasis</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00009">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Alteplase</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00513">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Aminocaproic Acid</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00029">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Anistreplase</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB01088">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Iloprost</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00015">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Reteplase</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00031">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Tenecteplase</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00302">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Tranexamic Acid</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00013">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>DrugBank</database>
<rdfs:comment>Urokinase</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/nextbio/20622">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>NextBio</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/pmap-cutdb/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PMAP-CutDB</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/arrayexpress/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>ArrayExpress</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/bgee/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Bgee</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/genevestigator/P00750">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Genevestigator</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/germonline/ENSG00000104368">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>GermOnline</database>
<rdfs:comment>Homo sapiens</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR016060">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Complement_control_module</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR006209">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>EGF</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR006210">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>EGF-like</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR013032">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>EGF-like_reg_CS</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR000742">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>EGF_3</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR000083">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Fibrnctn1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR000001">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Kringle</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR013806">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Kringle-like</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR018056">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Kringle_CS</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR018114">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Peptidase_S1/S6_AS</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR001254">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Peptidase_S1_S6</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR001314">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Peptidase_S1A</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR009003">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>Ser/Cys_Pept_Trypsin-like</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/gene3d/G3DSA:2.10.70.10">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Gene3D</database>
<rdfs:comment>Complement_control_module</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/gene3d/G3DSA:2.40.20.10">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Gene3D</database>
<rdfs:comment>Kringle</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF00008">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>EGF</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF00039">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>fn1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF00051">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>Kringle</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF00089">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>Trypsin</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530003F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prints/PR00722">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PRINTS</database>
<rdfs:comment>CHYMOTRYPSIN</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smart/SM00181">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMART</database>
<rdfs:comment>EGF</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300040">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smart/SM00058">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMART</database>
<rdfs:comment>FN1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300041">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smart/SM00130">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMART</database>
<rdfs:comment>KR</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300042">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smart/SM00020">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMART</database>
<rdfs:comment>Tryp_SPc</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300043">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/supfam/SSF57440">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SUPFAM</database>
<rdfs:comment>Kringle-like</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300044">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/supfam/SSF50494">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SUPFAM</database>
<rdfs:comment>Pept_Ser_Cys</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300045">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00022">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>EGF_1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300046">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS01186">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>EGF_2</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300047">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS50026">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>EGF_3</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300048">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS01253">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>FN1_1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300049">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS51091">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>FN1_2</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00021">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>KRINGLE_1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS50070">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>KRINGLE_2</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">2</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS50240">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>TRYPSIN_DOM</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00134">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>TRYPSIN_HIS</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00135">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>TRYPSIN_SER</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530004F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300050">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/AAB59510.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300051">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/CAA31489.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300052">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/AAO34406.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300053">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/AAH95403.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300054">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/AAK11956.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300055">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Tissue-type plasminogen activator</fullName>
<shortName>t-PA</shortName>
<shortName>t-plasminogen activator</shortName>
<shortName>tPA</shortName>
<ecName>3.4.21.68</ecName>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300056">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<internationalNonproprietaryName>Alteplase</internationalNonproprietaryName>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300057">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<internationalNonproprietaryName>Reteplase</internationalNonproprietaryName>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300058">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_5030303735300059" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300059">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Tissue-type plasminogen activator chain A</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503030373530005B" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Tissue-type plasminogen activator chain B</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005C">
<citation rdf:resource="http://purl.uniprot.org/citations/6337343" />
<citation rdf:resource="http://purl.uniprot.org/citations/6682760" />
<citation rdf:resource="http://purl.uniprot.org/citations/6433976" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005D">
<citation rdf:resource="http://purl.uniprot.org/citations/3133640" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005E">
<citation rdf:resource="http://purl.uniprot.org/citations/2107528" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530005F">
<citation rdf:resource="http://purl.uniprot.org/citations/14702039" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300060">
<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300061">
<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300062">
<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300063">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Gene" />
<skos:prefLabel>PLAT</skos:prefLabel>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300064">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Function_Annotation" />
<rdfs:comment>Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300065">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Catalytic_Activity_Annotation" />
<rdfs:comment>Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300066">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Subunit_Annotation" />
<rdfs:comment rdf:ID="_5030303735300067">Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300067">
<attribution rdf:resource="#_5030303735300068" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300069">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Subcellular_Location_Annotation" />
<locatedIn rdf:resource="#_503030373530006A" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006A">
<cellularComponent rdf:resource="http://purl.uniprot.org/locations/112" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Splicing_Annotation" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-1" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-2" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-3" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-4" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Tissue_Specificity_Annotation" />
<rdfs:comment>Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Annotation" />
<rdfs:comment rdf:ID="_503030373530006E">Both FN1 and one of the kringle domains are required for binding to fibrin.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006E">
<attribution rdf:resource="#_503030373530006F" />
<attribution rdf:resource="#_5030303735300070" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300071">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Annotation" />
<rdfs:comment rdf:ID="_5030303735300072">Both FN1 and EGF-like domains are important for binding to LRP1.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300072">
<attribution rdf:resource="#_503030373530006F" />
<attribution rdf:resource="#_5030303735300070" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300073">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Annotation" />
<rdfs:comment rdf:ID="_5030303735300074">The FN1 domain mediates binding to annexin A2.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300074">
<attribution rdf:resource="#_503030373530006F" />
<attribution rdf:resource="#_5030303735300070" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300075">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Annotation" />
<rdfs:comment rdf:ID="_5030303735300076">The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300076">
<attribution rdf:resource="#_503030373530006F" />
<attribution rdf:resource="#_5030303735300070" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300077">
<rdf:type rdf:resource="http://purl.uniprot.org/core/PTM_Annotation" />
<rdfs:comment>The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300078">
<rdf:type rdf:resource="http://purl.uniprot.org/core/PTM_Annotation" />
<rdfs:comment rdf:ID="_5030303735300079">Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300079">
<attribution rdf:resource="#_503030373530007A" />
<attribution rdf:resource="#_503030373530007B" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/PTM_Annotation" />
<rdfs:comment>N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/PTM_Annotation" />
<rdfs:comment>Characterization of O-linked glycan was studied in Bowes melanoma cell line.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disease_Annotation" />
<rdfs:comment>Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Pharmaceutical_Annotation" />
<rdfs:comment>Available under the names Activase (Genentech) and Retavase (Centocor and Roche) [Retavase is a fragment of TPA that contains kringle 2 and the protease domain; it was also known as BM 06.022]. Used in Acute Myocardial Infarction (AMI), in Acute Ischemic Stroke (AIS) and Pulmonary Embolism (PE) to initiate fibrinolysis.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300080">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Belongs to the peptidase S1 family.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300081">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Contains 1 EGF-like domain.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300082">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Contains 1 fibronectin type-I domain.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300083">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Contains 2 kringle domains.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300084">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Contains 1 peptidase S1 domain.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300085">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Signal_Peptide_Annotation" />
<range rdf:resource="#_5030303735300086" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300086">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">22</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000028348">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Propeptide_Annotation" />
<range rdf:resource="#_5030303735300087" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300087">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">23</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">32</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000028349">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Propeptide_Annotation" />
<rdfs:comment>Removed by plasmin</rdfs:comment>
<range rdf:resource="#_5030303735300088" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300088">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">33</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">35</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000028350">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
<rdfs:comment>Tissue-type plasminogen activator</rdfs:comment>
<range rdf:resource="#_5030303735300089" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300089">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">36</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">562</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000028351">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
<rdfs:comment>Tissue-type plasminogen activator chain A</rdfs:comment>
<range rdf:resource="#_503030373530008A" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">36</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">310</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000028352">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
<rdfs:comment>Tissue-type plasminogen activator chain B</rdfs:comment>
<range rdf:resource="#_503030373530008B" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">311</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">562</end>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Extent_Annotation" />
<rdfs:comment>Fibronectin type-I</rdfs:comment>
<range rdf:resource="#_503030373530008D" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">39</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">81</end>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Extent_Annotation" />
<rdfs:comment>EGF-like</rdfs:comment>
<range rdf:resource="#_503030373530008F" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530008F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">82</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">120</end>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300090">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Extent_Annotation" />
<rdfs:comment>Kringle 1</rdfs:comment>
<range rdf:resource="#_5030303735300091" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300091">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">127</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">208</end>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300092">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Extent_Annotation" />
<rdfs:comment>Kringle 2</rdfs:comment>
<range rdf:resource="#_5030303735300093" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300093">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">215</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">296</end>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300094">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Extent_Annotation" />
<rdfs:comment>Peptidase S1</rdfs:comment>
<range rdf:resource="#_5030303735300095" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300095">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">311</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">561</end>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300096">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Region_Annotation" />
<rdfs:comment>Important for binding to annexin A2</rdfs:comment>
<range rdf:resource="#_5030303735300097" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300097">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">42</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">52</end>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300098">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Active_Site_Annotation" />
<rdfs:comment>Charge relay system</rdfs:comment>
<range rdf:resource="#_5030303735300099" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300099">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">357</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">357</end>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Active_Site_Annotation" />
<rdfs:comment>Charge relay system</rdfs:comment>
<range rdf:resource="#_503030373530009B" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">406</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">406</end>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Active_Site_Annotation" />
<rdfs:comment>Charge relay system</rdfs:comment>
<range rdf:resource="#_503030373530009D" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">513</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">513</end>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Site_Annotation" />
<rdfs:comment>Important for binding to LRP1</rdfs:comment>
<range rdf:resource="#_503030373530009F" />
</rdf:Description>
<rdf:Description rdf:about="#_503030373530009F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">102</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">102</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A0">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Site_Annotation" />
<rdfs:comment>Not glycosylated</rdfs:comment>
<range rdf:resource="#_50303037353000A1" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">253</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">253</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Site_Annotation" />
<rdfs:comment>Important for single-chain activity</rdfs:comment>
<range rdf:resource="#_50303037353000A3" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A3">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">464</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">464</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A4">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Site_Annotation" />
<rdfs:comment>Important for single-chain activity</rdfs:comment>
<range rdf:resource="#_50303037353000A5" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A5">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">512</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">512</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/CAR_000029">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>O-linked (Fuc)</rdfs:comment>
<range rdf:resource="#_50303037353000A7" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A7">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">96</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">96</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A6">
<attribution rdf:resource="#_503030373530007B" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A8">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_50303037353000A9" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000A9">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">152</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">152</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/CAR_000030">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...); partial</rdfs:comment>
<range rdf:resource="#_50303037353000AA" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AA">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">219</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">219</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/CAR_000031">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_50303037353000AB" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AB">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">483</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">483</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AC">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000AE" />
<range rdf:resource="#_50303037353000AF" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AE">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">41</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">41</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">71</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">71</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000AD">
<attribution rdf:resource="#_50303037353000B0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000B3" />
<range rdf:resource="#_50303037353000B4" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B3">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">69</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">69</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B4">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">78</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">78</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B2">
<attribution rdf:resource="#_50303037353000B0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B5">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000B7" />
<range rdf:resource="#_50303037353000B8" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B7">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">86</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">86</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B8">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">97</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">97</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B6">
<attribution rdf:resource="#_50303037353000B0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B9">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000BB" />
<range rdf:resource="#_50303037353000BC" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BB">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">91</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">91</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BC">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">108</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">108</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BA">
<attribution rdf:resource="#_50303037353000B0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BD">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000BF" />
<range rdf:resource="#_50303037353000C0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">110</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">110</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000C0">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">119</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">119</end>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000BE">
<attribution rdf:resource="#_50303037353000B0" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000C1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000C3" />
<range rdf:resource="#_50303037353000C4" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000C3">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">127</begin>
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<range rdf:resource="#_50303037353000CC" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">296</begin>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
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<attribution rdf:resource="#_50303037353000B0" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000D7" />
<range rdf:resource="#_50303037353000D8" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">267</begin>
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<rdf:Description rdf:about="#_50303037353000D8">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">291</begin>
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<attribution rdf:resource="#_50303037353000B0" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
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<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">430</begin>
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<rdf:Description rdf:about="#_50303037353000DA">
<attribution rdf:resource="#_50303037353000B0" />
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<rdf:Description rdf:about="#_50303037353000DD">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000DF" />
<range rdf:resource="#_50303037353000E0" />
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<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">342</begin>
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<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">519</begin>
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<status rdf:resource="http://purl.uniprot.org/core/By_Similarity" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000E9">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000EB" />
<range rdf:resource="#_50303037353000EC" />
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<rdf:Description rdf:about="#_50303037353000EB">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">476</begin>
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<rdf:Description rdf:about="#_50303037353000EC">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">492</begin>
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<status rdf:resource="http://purl.uniprot.org/core/By_Similarity" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000ED">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disulfide_Bond_Annotation" />
<range rdf:resource="#_50303037353000EF" />
<range rdf:resource="#_50303037353000F0" />
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<rdf:Description rdf:about="#_50303037353000EF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">509</begin>
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<rdf:Description rdf:about="#_50303037353000F0">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">537</begin>
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<rdf:Description rdf:about="#_50303037353000EE">
<status rdf:resource="http://purl.uniprot.org/core/By_Similarity" />
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VSP_028029">
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<rdfs:comment>In isoform 4.</rdfs:comment>
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<range rdf:resource="#_50303037353000F1" />
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<rdf:Description rdf:about="#_50303037353000F1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">40</end>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VSP_015957">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Sequence_Annotation" />
<rdfs:comment>In isoform 3.</rdfs:comment>
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<rdf:Description rdf:about="#_50303037353000F2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">39</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">85</end>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VSP_028030">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Sequence_Annotation" />
<rdfs:comment>In isoform 4.</rdfs:comment>
<substitution></substitution>
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<rdf:Description rdf:about="#_50303037353000F3">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">79</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">208</end>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VSP_005411">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Sequence_Annotation" />
<rdfs:comment>In isoform 2.</rdfs:comment>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">269</begin>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VSP_005412">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Sequence_Annotation" />
<rdfs:comment>In isoform 2.</rdfs:comment>
<substitution></substitution>
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<rdf:Description rdf:about="#_50303037353000F5">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">292</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">562</end>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VAR_020181">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Natural_Variant_Annotation" />
<substitution>D</substitution>
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs8178733" />
<range rdf:resource="#_50303037353000F7" />
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<rdf:Description rdf:about="#_50303037353000F7">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">34</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">34</end>
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<rdf:Description rdf:about="#_50303037353000F6">
<attribution rdf:resource="#_50303037353000F8" />
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VAR_038732">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Natural_Variant_Annotation" />
<substitution>S</substitution>
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs8178747" />
<range rdf:resource="#_50303037353000FA" />
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<rdf:Description rdf:about="#_50303037353000FA">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">136</begin>
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<rdf:Description rdf:about="#_50303037353000F9">
<attribution rdf:resource="#_50303037353000F8" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VAR_038733">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Natural_Variant_Annotation" />
<substitution>T</substitution>
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs8178748" />
<range rdf:resource="#_50303037353000FC" />
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<rdf:Description rdf:about="#_50303037353000FC">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">146</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">146</end>
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<rdf:Description rdf:about="#_50303037353000FB">
<attribution rdf:resource="#_50303037353000F8" />
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/VAR_011783">
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<substitution>W</substitution>
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<range rdf:resource="#_50303037353000FE" />
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<rdf:Description rdf:about="#_50303037353000FE">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">164</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">164</end>
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<attribution rdf:resource="#_50303037353000F8" />
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<rdf:Description rdf:about="#_50303037353000FF">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
<conflictingSequence rdf:resource="#_5030303735300050" />
<substitution>T</substitution>
<range rdf:resource="#_50303037353000100" />
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<rdf:Description rdf:about="#_50303037353000100">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">93</begin>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
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<substitution>NA</substitution>
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<rdf:Description rdf:about="#_50303037353000102">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">159</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">160</end>
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<rdf:Description rdf:about="#_50303037353000103">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
<conflictingSequence rdf:resource="#_5030303735300052" />
<substitution>N</substitution>
<range rdf:resource="#_50303037353000104" />
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<rdf:Description rdf:about="#_50303037353000104">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">247</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">247</end>
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<rdf:Description rdf:about="#_50303037353000105">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
<conflictingSequence rdf:resource="#_5030303735300053" />
<substitution>S</substitution>
<range rdf:resource="#_50303037353000106" />
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<rdf:Description rdf:about="#_50303037353000106">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">283</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">283</end>
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<rdf:Description rdf:about="#_50303037353000107">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
<conflictingSequence rdf:resource="#_5030303735300054" />
<substitution>EE</substitution>
<range rdf:resource="#_50303037353000108" />
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<rdf:Description rdf:about="#_50303037353000108">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">333</begin>
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<rdfs:comment>May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.</rdfs:comment>
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<rdfs:comment>No experimental confirmation available.</rdfs:comment>
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-3" />
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<rdf:Description rdf:about="#_5030303735300015B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Caution_Annotation" />
<rdfs:comment>No experimental confirmation available.</rdfs:comment>
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P00750-4" />
</rdf:Description>
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<rdf:Description rdf:about="#_5030303735300015E">
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<rdf:Description rdf:about="#_50303037353000160">
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<attribution rdf:resource="#_50303037353000162" />
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<attribution rdf:resource="#_50303037353000164" />
<attribution rdf:resource="#_50303037353000165" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000166">
<attribution rdf:resource="#_50303037353000167" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000168">
<attribution rdf:resource="#_50303037353000169" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300016A">
<attribution rdf:resource="#_5030303735300016B" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300016C">
<attribution rdf:resource="#_5030303735300016D" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/isoforms/P00750-1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Simple_Sequence" />
<modified rdf:datatype="http://www.w3.org/2001/XMLSchema#date">1986-07-21</modified>
<version rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</version>
<precursor rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</precursor>
<mass rdf:datatype="http://www.w3.org/2001/XMLSchema#int">62917</mass>
<crc64Checksum>B7EC9B1A5E3FDC4D</crc64Checksum>
<name>1</name>
<name>Long</name>
<rdf:value>MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK DVPGVYTKVT NYLDWIRDNM RP</rdf:value>
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<rdf:Description rdf:about="http://purl.uniprot.org/isoforms/P00750-2">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Modified_Sequence" />
<name>2</name>
<name>Short</name>
<basedOn rdf:resource="http://purl.uniprot.org/isoforms/P00750-1" />
<modification rdf:resource="http://purl.uniprot.org/annotation/VSP_005411" />
<modification rdf:resource="http://purl.uniprot.org/annotation/VSP_005412" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/isoforms/P00750-3">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Modified_Sequence" />
<name>3</name>
<basedOn rdf:resource="http://purl.uniprot.org/isoforms/P00750-1" />
<modification rdf:resource="http://purl.uniprot.org/annotation/VSP_015957" />
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<rdf:Description rdf:about="http://purl.uniprot.org/isoforms/P00750-4">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Modified_Sequence" />
<name>4</name>
<name>Neonatal</name>
<basedOn rdf:resource="http://purl.uniprot.org/isoforms/P00750-1" />
<modification rdf:resource="http://purl.uniprot.org/annotation/VSP_028029" />
<modification rdf:resource="http://purl.uniprot.org/annotation/VSP_028030" />
</rdf:Description>
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<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IDA" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-04-23</date>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300015F">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/UniProtKB-SubCell" />
<evidence rdf:resource="http://purl.uniprot.org/core/IEA" />
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000161">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IPI" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-03-03</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000162">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IPI" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-02-19</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000164">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IDA" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-03-30</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000165">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IDA" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-02-19</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000167">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/ProtInc" />
<evidence rdf:resource="http://purl.uniprot.org/core/TAS" />
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<rdf:Description rdf:about="#_50303037353000169">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/BHF-UCL" />
<evidence rdf:resource="http://purl.uniprot.org/core/IDA" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-03-31</date>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300016B">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/ProtInc" />
<evidence rdf:resource="http://purl.uniprot.org/core/TAS" />
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<rdf:Description rdf:about="#_5030303735300016D">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/ProtInc" />
<evidence rdf:resource="http://purl.uniprot.org/core/TAS" />
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300068">
<rdfs:label>EC1</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/11384978" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530006F">
<rdfs:label>EC2</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/8613982" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_5030303735300070">
<rdfs:label>EC3</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/9305622" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007A">
<rdfs:label>EC4</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/2513186" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_503030373530007B">
<rdfs:label>EC5</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/1900431" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000B0">
<rdfs:label>EC6</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="http://purl.uniprot.org/citations/1645336" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="#_50303037353000F8">
<rdfs:label>EC7</rdfs:label>
<manual rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</manual>
<source rdf:resource="#_5030303735300013" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-07-01</date>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/uniprot/P56540">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Protein" />
<reviewed rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</reviewed>
<created rdf:datatype="http://www.w3.org/2001/XMLSchema#date">1998-07-15</created>
<modified rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-08-10</modified>
<version rdf:datatype="http://www.w3.org/2001/XMLSchema#int">31</version>
<mnemonic>CBBQ_CHRVI</mnemonic>
<citation rdf:resource="http://purl.uniprot.org/citations/2708310" rdf:ID="_503536353430001" />
<citation rdf:resource="http://purl.uniprot.org/citations/7883189" rdf:ID="_503536353430002" />
<rdfs:seeAlso rdf:resource="#_503536353430003" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/proteinmodelportal/P56540" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/smr/P56540" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/interpro/IPR011704" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/pfam/PF07728" rdf:ID="_503536353430004" />
<recommendedName rdf:resource="#_503536353430005" />
<organism rdf:resource="http://purl.uniprot.org/taxonomy/1049" />
<encodedBy rdf:resource="#_503536353430006" />
<annotation rdf:resource="#_503536353430007" />
<annotation rdf:resource="#_503536353430008" />
<annotation rdf:resource="http://purl.uniprot.org/annotation/PRO_0000219562" />
<annotation rdf:resource="#_50353635343000B" rdf:ID="_50353635343000C" />
<annotation rdf:resource="#_50353635343000E" />
<existence rdf:resource="http://purl.uniprot.org/core/Inferred_from_Homology_Existence" />
<classifiedWith rdf:resource="http://purl.uniprot.org/keywords/67" />
<classifiedWith rdf:resource="http://purl.uniprot.org/go/0005524" rdf:ID="_5035363534300010" />
<classifiedWith rdf:resource="http://purl.uniprot.org/go/0016887" rdf:ID="_5035363534300012" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P56540-1" />
<attribution rdf:resource="#_5035363534300011" />
<attribution rdf:resource="#_5035363534300013" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/citations/2708310">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Journal_Citation" />
<title>Expressed genes for plant-type ribulose 1,5-bisphosphate carboxylase/oxygenase in the photosynthetic bacterium Chromatium vinosum, which possesses two complete sets of the genes.</title>
<author>Viale A.M.</author>
<author>Kobayashi H.</author>
<author>Akazawa T.</author>
<skos:exactMatch rdf:resource="http://purl.uniprot.org/medline/89213919" />
<skos:exactMatch rdf:resource="http://purl.uniprot.org/pubmed/2708310" />
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">1989</date>
<name>J. Bacteriol.</name>
<volume>171</volume>
<pages>2391-2400</pages>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430001">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Citation_Statement" />
<scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/citations/7883189">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Journal_Citation" />
<title>Genes encoding RubisCO in Pseudomonas hydrogenothermophila are followed by a novel cbbQ gene similar to nirQ of the denitrification gene cluster from Pseudomonas species.</title>
<author>Yokoyama K.</author>
<author>Hayashi N.R.</author>
<author>Arai H.</author>
<author>Chung S.Y.</author>
<author>Igarashi Y.</author>
<author>Kodama T.</author>
<skos:exactMatch rdf:resource="http://purl.uniprot.org/medline/95189107" />
<skos:exactMatch rdf:resource="http://purl.uniprot.org/pubmed/7883189" />
<dc:identifier>doi:10.1016/0378-1119(94)00808-6</dc:identifier>
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">1995</date>
<name>Gene</name>
<volume>153</volume>
<pages>75-79</pages>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430002">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Citation_Statement" />
<scope>IDENTIFICATION</scope>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430003">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Nucleotide_Resource" />
<database>EMBL</database>
<locatedOn rdf:resource="http://purl.uniprot.org/embl/M26396" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/embl/M26396">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Genomic_DNA" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/proteinmodelportal/P56540">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>ProteinModelPortal</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/smr/P56540">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>SMR</database>
<rdfs:comment>10-72</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR011704">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>ATPase_AAA-5</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF07728">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>AAA_5</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430004">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430005">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Protein CbbQ</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430006">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Gene" />
<skos:prefLabel>cbbQ</skos:prefLabel>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430007">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Function_Annotation" />
<rdfs:comment>May affect the post-translational activation and/or assembly of the oligomeric structure of RuBisCO.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503536353430008">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Belongs to the CbbQ/NirQ/NorQ/GpvN family.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000219562">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
<rdfs:comment>Protein CbbQ</rdfs:comment>
<range rdf:resource="#_503536353430009" />
</rdf:Description>
<rdf:Description rdf:about="#_503536353430009">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</begin>
<end rdf:ID="_50353635343000A" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">74</end>
</rdf:Description>
<rdf:Description rdf:about="#_50353635343000A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<limit rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</limit>
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<rdf:Description rdf:about="#_50353635343000B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/NP_Binding_Annotation" />
<rdfs:comment>ATP</rdfs:comment>
<range rdf:resource="#_50353635343000D" />
</rdf:Description>
<rdf:Description rdf:about="#_50353635343000D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">41</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">48</end>
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<status rdf:resource="http://purl.uniprot.org/core/Potential" />
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<rdf:Description rdf:about="#_50353635343000E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Non-terminal_Residue_Annotation" />
<range rdf:resource="#_50353635343000F" />
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<rdf:Description rdf:about="#_50353635343000F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">74</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">74</end>
</rdf:Description>
<rdf:Description rdf:about="#_5035363534300010">
<attribution rdf:resource="#_5035363534300011" />
</rdf:Description>
<rdf:Description rdf:about="#_5035363534300012">
<attribution rdf:resource="#_5035363534300013" />
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<rdf:Description rdf:about="http://purl.uniprot.org/isoforms/P56540-1">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Simple_Sequence" />
<modified rdf:datatype="http://www.w3.org/2001/XMLSchema#date">1998-07-15</modified>
<version rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</version>
<fragment>single</fragment>
<mass rdf:datatype="http://www.w3.org/2001/XMLSchema#int">8377</mass>
<crc64Checksum>B7AB23BF4DEA291C</crc64Checksum>
<rdf:value>MSDIDRNQFL IDHEPYYRPV SNEVALYEAA YAARMPVMLK GPTGCGKTRF VEYMAWKLGK PLITVACNED MTAS</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#_5035363534300011">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/UniProtKB-KW" />
<evidence rdf:resource="http://purl.uniprot.org/core/IEA" />
</rdf:Description>
<rdf:Description rdf:about="#_5035363534300013">
<dc:creator rdf:resource="http://purl.uniprot.org/goa-projects/InterPro" />
<evidence rdf:resource="http://purl.uniprot.org/core/IEA" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/uniprot/Q51858">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Protein" />
<reviewed rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</reviewed>
<created rdf:datatype="http://www.w3.org/2001/XMLSchema#date">1998-07-15</created>
<modified rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2010-08-10</modified>
<version rdf:datatype="http://www.w3.org/2001/XMLSchema#int">36</version>
<mnemonic>CBBQ_PSEHY</mnemonic>
<citation rdf:resource="http://purl.uniprot.org/citations/7883189" rdf:ID="_513531383538001" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/embl-cds/BAA06439.1" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/proteinmodelportal/Q51858" />
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/smr/Q51858" />
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<author>Hayashi N.R.</author>
<author>Arai H.</author>
<author>Chung S.Y.</author>
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<database>SMR</database>
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<fullName>Protein CbbQ</fullName>
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<skos:prefLabel>cbbQ</skos:prefLabel>
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<rdfs:comment>May affect the post-translational activation and/or assembly of the oligomeric structure of RuBisCO.</rdfs:comment>
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<rdfs:comment>Protein CbbQ</rdfs:comment>
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<rdfs:comment>ATP</rdfs:comment>
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<reviewed rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</reviewed>
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<title>Structure and ANR-dependent transcription of the nir genes for denitrification from Pseudomonas aeruginosa.</title>
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<title>Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.</title>
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<author>Pham X.-Q.T.</author>
<author>Erwin A.L.</author>
<author>Mizoguchi S.D.</author>
<author>Warrener P.</author>
<author>Hickey M.J.</author>
<author>Brinkman F.S.L.</author>
<author>Hufnagle W.O.</author>
<author>Kowalik D.J.</author>
<author>Lagrou M.</author>
<author>Garber R.L.</author>
<author>Goltry L.</author>
<author>Tolentino E.</author>
<author>Westbrock-Wadman S.</author>
<author>Yuan Y.</author>
<author>Brody L.L.</author>
<author>Coulter S.N.</author>
<author>Folger K.R.</author>
<author>Kas A.</author>
<author>Larbig K.</author>
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<author>Spencer D.H.</author>
<author>Wong G.K.-S.</author>
<author>Wu Z.</author>
<author>Paulsen I.T.</author>
<author>Reizer J.</author>
<author>Saier M.H. Jr.</author>
<author>Hancock R.E.W.</author>
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<name>Nature</name>
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<title>The DNA sequence, annotation and analysis of human chromosome 3.</title>
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<dc:identifier>doi:10.1038/nature04728</dc:identifier>
<date rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2006</date>
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<title>The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).</title>
<group>The MGC Project Team</group>
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<dc:identifier>doi:10.1101/gr.2596504</dc:identifier>
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<name>Genome Res.</name>
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<scope>NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]</scope>
<scope>VARIANT ARG-78</scope>
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<title>Analysis of a putative tumor suppressor gene region of 100 kb at chromosome 3p21.1 in conventional renal cell carcinoma.</title>
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<author>Hanke S.</author>
<author>Chudek J.</author>
<author>Kovacs G.</author>
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<scope>NUCLEOTIDE SEQUENCE [MRNA] OF 113-594</scope>
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<rdfs:label>Kidney</rdfs:label>
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<database>UniGene</database>
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<database>ProteinModelPortal</database>
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<database>STRING</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/phosphosite/Q8NE62">
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<database>PhosphoSite</database>
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<database>Ensembl</database>
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<transcribedFrom rdf:resource="http://purl.uniprot.org/ensembl/ENSG00000016391" />
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<database>GeneID</database>
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<database>KEGG</database>
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<database>UCSC</database>
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<database>GeneCards</database>
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<database>HGNC</database>
<rdfs:comment>CHDH</rdfs:comment>
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<database>eggNOG</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/hovergen/HBG023639">
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<database>HOVERGEN</database>
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<database>InParanoid</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/oma/SRDEYSY">
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<database>OMA</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/orthodb/EOG9962C6">
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<rdf:Description rdf:about="http://purl.uniprot.org/phylomedb/Q8NE62">
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<database>PhylomeDB</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/brenda/1.1.99.1">
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<database>BRENDA</database>
<rdfs:comment>247</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/drugbank/DB00122">
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<database>DrugBank</database>
<rdfs:comment>Choline</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/nextbio/59691">
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<database>NextBio</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/arrayexpress/Q8NE62">
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<database>ArrayExpress</database>
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<rdf:Description rdf:about="http://purl.uniprot.org/bgee/Q8NE62">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Bgee</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/cleanex/HS_CHDH">
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<database>CleanEx</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/genevestigator/Q8NE62">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Genevestigator</database>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/germonline/ENSG00000016391">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>GermOnline</database>
<rdfs:comment>Homo sapiens</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR012132">
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<database>InterPro</database>
<rdfs:comment>GMC_OxRdtase</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR000172">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>GMC_OxRdtase_N</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/interpro/IPR007867">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>InterPro</database>
<rdfs:comment>GMC_OxRtase_C</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF05199">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>GMC_oxred_C</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_51384e453632008">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/pfam/PF00732">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>Pfam</database>
<rdfs:comment>GMC_oxred_N</rdfs:comment>
</rdf:Description>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
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<rdf:Description rdf:about="http://purl.uniprot.org/pirsf/PIRSF000137">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PIRSF</database>
<rdfs:comment>Alcohol_oxidase</rdfs:comment>
</rdf:Description>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00623">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Resource" />
<database>PROSITE</database>
<rdfs:comment>GMC_OXRED_1</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_51384e45363200B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
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<rdf:Description rdf:about="http://purl.uniprot.org/prosite/PS00624">
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<database>PROSITE</database>
<rdfs:comment>GMC_OXRED_2</rdfs:comment>
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<rdf:Description rdf:about="#_51384e45363200C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Domain_Assignment_Statement" />
<hits rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</hits>
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<rdf:Description rdf:about="#_51384e45363200D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/External_Sequence" />
<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/CAB75961.1" />
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<rdf:Description rdf:about="#_51384e45363200E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Choline dehydrogenase, mitochondrial</fullName>
<shortName>CDH</shortName>
<shortName>CHD</shortName>
<ecName>1.1.99.1</ecName>
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<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
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<citation rdf:resource="#_51384e453632004" />
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<rdf:Description rdf:about="#_51384e4536320011">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Gene" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Catalytic_Activity_Annotation" />
<rdfs:comment>Choline + acceptor = betaine aldehyde + reduced acceptor.</rdfs:comment>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Cofactor_Annotation" />
<rdfs:comment>FAD (By similarity).</rdfs:comment>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Pathway_Annotation" />
<rdfs:comment>Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.</rdfs:comment>
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/unipathway/289.529.182.385" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Subcellular_Location_Annotation" />
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<rdfs:comment>Belongs to the GMC oxidoreductase family.</rdfs:comment>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Transit_Peptide_Annotation" />
<rdfs:comment>Mitochondrion</rdfs:comment>
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<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012329">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/NP_Binding_Annotation" />
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<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">71</end>
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Active_Site_Annotation" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Modified_Residue_Annotation" />
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<substitution>A</substitution>
<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs9001" />
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<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs12676" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Natural_Variant_Annotation" />
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<rdfs:seeAlso rdf:resource="http://purl.uniprot.org/dbsnp/rs34974961" />
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<rdf:type rdf:resource="http://purl.uniprot.org/core/Sequence_Conflict_Annotation" />
<conflictingSequence rdf:resource="#_51384e45363200D" />
<substitution>A</substitution>
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<translatedFrom rdf:resource="http://purl.uniprot.org/embl-cds/AAA58617.1" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390028">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulins</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390029">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Proepithelin</fullName>
<shortName>PEPI</shortName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503238373939002B" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Acrogranin</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503238373939002D" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Paragranulin</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503238373939002F" />
<alternativeName rdf:resource="#_5032383739390030" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939002F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-1</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390030">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin G</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390031">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_5032383739390032" />
<alternativeName rdf:resource="#_5032383739390033" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390032">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-2</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390033">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin F</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390034">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_5032383739390035" />
<alternativeName rdf:resource="#_5032383739390036" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390035">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-3</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390036">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin B</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390037">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_5032383739390038" />
<alternativeName rdf:resource="#_5032383739390039" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390038">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-4</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390039">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin A</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503238373939003B" />
<alternativeName rdf:resource="#_503238373939003C" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-5</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin C</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_503238373939003E" />
<alternativeName rdf:resource="#_503238373939003F" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-6</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939003F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin D</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390040">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Part" />
<recommendedName rdf:resource="#_5032383739390041" />
<alternativeName rdf:resource="#_5032383739390042" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390041">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin-7</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390042">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Structured_Name" />
<fullName>Granulin E</fullName>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390043">
<citation rdf:resource="http://purl.uniprot.org/citations/1618805" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390044">
<citation rdf:resource="http://purl.uniprot.org/citations/1542665" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390045">
<citation rdf:resource="#_503238373939008" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390046">
<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390047">
<citation rdf:resource="http://purl.uniprot.org/citations/15489334" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390048">
<citation rdf:resource="http://purl.uniprot.org/citations/2268320" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390049">
<citation rdf:resource="http://purl.uniprot.org/citations/19159218" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Gene" />
<skos:prefLabel>GRN</skos:prefLabel>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Function_Annotation" />
<rdfs:comment>Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Function_Annotation" />
<rdfs:comment>Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Subcellular_Location_Annotation" />
<locatedIn rdf:resource="#_503238373939004E" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004E">
<cellularComponent rdf:resource="http://purl.uniprot.org/locations/243" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939004F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Alternative_Splicing_Annotation" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P28799-1" />
<sequence rdf:resource="http://purl.uniprot.org/isoforms/P28799-2" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390050">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Tissue_Specificity_Annotation" />
<rdfs:comment>In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390051">
<rdf:type rdf:resource="http://purl.uniprot.org/core/PTM_Annotation" />
<rdfs:comment>Granulins are disulfide bridged.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390052">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Disease_Annotation" />
<rdfs:comment rdf:ID="_5032383739390053">Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390053">
<attribution rdf:resource="#_5032383739390054" />
<attribution rdf:resource="#_5032383739390055" />
<attribution rdf:resource="#_5032383739390056" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390057">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Similarity_Annotation" />
<rdfs:comment>Belongs to the granulin family.</rdfs:comment>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390058">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Signal_Peptide_Annotation" />
<range rdf:resource="#_503238373939005A" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">1</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">17</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390059">
<status rdf:resource="http://purl.uniprot.org/core/Potential" />
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012693">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Chain_Annotation" />
<rdfs:comment>Acrogranin</rdfs:comment>
<range rdf:resource="#_503238373939005B" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">18</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">593</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012694">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Paragranulin</rdfs:comment>
<range rdf:resource="#_503238373939005C" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">18</begin>
<end rdf:ID="_503238373939005D" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">47</end>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012695">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-1</rdfs:comment>
<range rdf:resource="#_503238373939005E" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005E">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:ID="_503238373939005F" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">58</begin>
<end rdf:ID="_5032383739390060" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">113</end>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939005F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390060">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012696">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-2</rdfs:comment>
<range rdf:resource="#_5032383739390061" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390061">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:ID="_5032383739390062" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">123</begin>
<end rdf:ID="_5032383739390063" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">179</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390062">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390063">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012697">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-3</rdfs:comment>
<range rdf:resource="#_5032383739390064" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390064">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">206</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">261</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012698">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-4</rdfs:comment>
<range rdf:resource="#_5032383739390065" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390065">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">281</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">336</end>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012699">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-5</rdfs:comment>
<range rdf:resource="#_5032383739390066" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390066">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">364</begin>
<end rdf:ID="_5032383739390067" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">417</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390067">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012700">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-6</rdfs:comment>
<range rdf:resource="#_5032383739390068" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390068">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">442</begin>
<end rdf:ID="_5032383739390069" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">496</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390069">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="http://purl.uniprot.org/annotation/PRO_0000012701">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Peptide_Annotation" />
<rdfs:comment>Granulin-7</rdfs:comment>
<range rdf:resource="#_503238373939006A" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006A">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:ID="_503238373939006B" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">518</begin>
<end rdf:ID="_503238373939006C" rdf:datatype="http://www.w3.org/2001/XMLSchema#int">573</end>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006B">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006C">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Endpoint_Statement" />
<certain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</certain>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006D">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_503238373939006F" />
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006F">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">118</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">118</end>
</rdf:Description>
<rdf:Description rdf:about="#_503238373939006E">
<status rdf:resource="http://purl.uniprot.org/core/Potential" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390070">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_5032383739390072" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390072">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">236</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">236</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390071">
<status rdf:resource="http://purl.uniprot.org/core/Potential" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390073">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_5032383739390075" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390075">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">265</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">265</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390074">
<attribution rdf:resource="#_5032383739390076" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390077">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_5032383739390078" />
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390078">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Range" />
<begin rdf:datatype="http://www.w3.org/2001/XMLSchema#int">368</begin>
<end rdf:datatype="http://www.w3.org/2001/XMLSchema#int">368</end>
</rdf:Description>
<rdf:Description rdf:about="#_5032383739390079">
<rdf:type rdf:resource="http://purl.uniprot.org/core/Glycosylation_Annotation" />
<rdfs:comment>N-linked (GlcNAc...)</rdfs:comment>
<range rdf:resource="#_503238373939007B" />
</rdf:Description>
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<rdfs:comment>In isoform 2.</rdfs:comment>
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<rdfs:label>EC2</rdfs:label>
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<rdfs:label>EC3</rdfs:label>
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<rdfs:label>EC4</rdfs:label>
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<mnemonic>YCA2_BPT4</mnemonic>
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