# STOCKHOLM 1.0
#=GF ID   SH3_11
#=GF AC   PF18103.3
#=GF DE   Retroviral integrase C-terminal SH3 domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00899
#=GF GA   25.00 25.00;
#=GF TC   25.20 78.10;
#=GF NC   24.90 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Integrase
#=GF WK   SH3_domain
#=GF CL   CL0010
#=GF RN   [1]
#=GF RM   20118915
#=GF RT   Retroviral intasome assembly and inhibition of DNA strand
#=GF RT   transfer.
#=GF RA   Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P;
#=GF RL   Nature. 2010;464:232-236.
#=GF DR   INTERPRO; IPR040903;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the carboxy-terminal domain (CTD) found in retroviral
#=GF CC   integrase, an essential retroviral enzyme that binds both
#=GF CC   termini of linear viral DNA and inserts them into a host cell
#=GF CC   chromosome. The CTD adopts an SH3-like fold. Each CTD makes
#=GF CC   contact with the phosphodiester backbone of both viral DNA
#=GF CC   molecules, essentially crosslinking the structure [1].
#=GF SQ   1
#=GS POL_SFVCP/1064-1126  AC Q87040.1
POL_SFVCP/1064-1126             RSWSPVVGQLVQERVARPASLRPRWHKPSTVLEVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ
#=GC seq_cons                   RSWSPVVGQLVQERVARPASLRPRWHKPSTVLEVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ
//
