# STOCKHOLM 1.0
#=GF ID   3Beta_HSD
#=GF AC   PF01073.21
#=GF DE   3-beta hydroxysteroid dehydrogenase/isomerase family
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_504 (release 3.0)
#=GF GA   22.00 22.00;
#=GF TC   22.00 22.00;
#=GF NC   21.90 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   3β-Hydroxysteroid_dehydrogenase
#=GF CL   CL0063
#=GF RN   [1]
#=GF RM   1562516
#=GF RT   Structure and tissue-specific expression of 3
#=GF RT   beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in
#=GF RT   human and rat classical and peripheral steroidogenic tissues. 
#=GF RA   Labrie F, Simard J, Luu-The V, Pelletier G, Belanger A, Lachance
#=GF RA   Y, Zhao HF, Labrie C, Breton N, de Launoit Y, et al 
#=GF RL   J Steroid Biochem Mol Biol 1992;41:421-435.
#=GF DR   INTERPRO; IPR002225;
#=GF DR   HOMSTRAD; Epimerase;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene 
#=GF CC   isomerase (3 beta-HSD) catalyses the oxidation and isomerisation
#=GF CC    of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene 
#=GF CC   steroid precursors into the corresponding 4-ene-ketosteroids
#=GF CC   necessary for the formation of all classes of steroid hormones.
#=GF SQ   8
#=GS 3BHS_FOWPN/7-287     AC Q67477.2
#=GS Q98318_MCV1/5-278    AC Q98318.1
#=GS 3BHS_VACCW/5-274     AC P26670.1
#=GS 3BHS1_HUMAN/7-288    AC P14060.2
#=GS 3BHS1_MOUSE/7-288    AC P24815.3
#=GS O22813_ARATH/15-299  AC O22813.1
#=GS HSDD3_ARATH/16-287   AC A9X4U2.2
#=GS ERG26_YEAST/8-280    AC P53199.1
3BHS_FOWPN/7-287                VVTGGCGFLGRHIINNLILFESSLKEVRVYD......IRIDQWLLDLVEKCNII.KIVPVIGDVRNKSTLDEALRSADVVIHIASINDVAG.KFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIRGNENTYYQSN..HKEAYPLSKQLSEKYILEANG.TMSNIGLRLCTCALRPLGVFGEYCPVLETLYRRSYKSR.KMYKYADDKVFHSRVYAGNVAWMHILAARNMIENGQ....HSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRN.T...CLPL
Q98318_MCV1/5-278               AVTGGGGFIGSYIVRALLQCERTLIELRVID......VRWGTKV..SSRNVNVV....YIYCDVCDTARLCAALEGVDVLIHTAGLVDVMG.EYSEDEIYRANVHGTHSALSACVCAGVRFVVYTSSMEVVGPNMRAEPFV.GDEKTEYESC..HQHCYPRSKAEAEELVLSSNGRRVRGGQ.RMLTCALRPPGVYGEGNQLLLRLAKNYVRMGLHVPRTVCENALQSRVYVGNVAWMHVLAARALQEP......DSRLPGNAYFCYDHSPCMDYEAFNVMLLRSFGVELGGP....RLPR
3BHS_VACCW/5-274                AVTGGAGFLGRYIVKLLISADD.VQEIRVID......IVEDPQP..ITSKVKVIN...YIQCDINDFDKVREALDGVNLIIHTAALVDVFG.KYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFI.GHEHTLYDIS..PGHVYAKSKRMAEQLVMKANNSVIMNGA.KLYTCCLRPTGIYGEGDKLTKVFYEQCKQHGNIMYRTVDDDAVHSRVYVGNVAWMHVLAAKYIQYP......GSEIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSR........
3BHS1_HUMAN/7-288               LVTGAGGFLGQRIIRLLVKEKE.LKEIRVLD......KAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFG.VTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENT..WPAPYPHSKKLAEKAVLAANGWNLKNGG.TLYTCALRPMYIYGEGSRFLSASINEALNNN.GILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKK....APSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRW...SFPL
3BHS1_MOUSE/7-288               LVTGAGGFVGQRIIKMLVQEKE.LQEVRALD......KVFRPETKEEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTG.VIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHEST..WSDPYPYSKKMAEKAVLAANGSMLKNGG.TLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSI.ANPVYVENVAWAHILAARGLRDPKK....STSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASW...SLPL
O22813_ARATH/15-299             VVTGGLGFVGAALCLELVRRG..ARQVRSFD......LRHSSPWSDDLKNSGVR....CIQGDVTKKQDVDNALDGADCVLHLASYGMSGKEMLRFGRCDEVNINGTCNVLEAAFKHEITRIVYVSTYNVVFG...GKEILNGNEGLPYFPLDDHVDAYSRTKSIAEQLVLKSNGRPFKNGGKRMYTCAIRPAAIYGPGEDRHLPRIVTLTKLGLALFKIGEPSVKSDWIYVENLVLAIILASMGLLDDIPGREGQPVAAGQPYFVSDGYPVN.TFEFLRPLLKSLDYDLPKCTISVPFAL
HSDD3_ARATH/16-287              VVLGGRGFIGRSLVSRLLRLGN..WTVRVADSGHTLHLDESDSLLEDALSSGRAS...YHCVDVRDKPQIVKVTEGSYVVFYM.GATDLRS.HDYFD.CYKVIVQGTRNVISACRESGVRKLIYNSTADVVFD..GSQPIRDGDESLRRPLK..FQSMLTDFKAQAEALIKLANN...RDG...LLTCALRSSIVFGPGDTEFVPFLVNLAKSGYAKFILGSGENISDFTYSENVSHAHICAVKALDSQ......MEFVAGKEFFITNLKPVR.FWDFVSHIVEGLGYPRPS.I...KLPV
ERG26_YEAST/8-280               LIIGGSGFLGLHLIQQFFDINP.KPDIHIFD......VRDLPEKLSKQFTFNVDDI.KFHKGDLTSPDDMENAINESKANVVVHCASPMHG..QNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFN...GQDVHNADETWPIPEV..PMDAYNETKAIAEDMVLKAND.....PSSDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQKLLDPKT....RTAVSGETFFITNDTPTY.FWALARTVWKADGHIDKHVI...VLKR
#=GC seq_cons                   lVTGGuGFlGppIlptLlptcp.lpElRVhD......lchssphh-chppsslts...hlpGDlpDpsplccAlcGssVlIHsAulsDVtG.hhsp-pIhcVNlpGTpNlL-AClpsGVphllYTSSh-VlGPN.hucsllsGcEpp.apss..atcsYscSKphAEchVLpANG..h+NGu.cLhTCALRPsuIYGEGsphlhshlppshKpG.thaphucssshpshVYVGNVAWAHILAA+uLp-Ph.....poslsGpsYFloDsoPsppYcsFNhpLhKshGhchsu.h...sLPl
//
